PUBLIC HEALTH PHARMACY

PHYSICAL PHARMACEUTICS-I BP302T

UNIT -01

  • Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. 

  • Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions.

  • Partially miscible liquids, Critical solution temperature and applications. 

  • Distribution law, its limitations and applications. 

UNIT -02

  • States of Matter and properties of matter: State of matter, changes in the state of matter, latent heats, vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols– inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid- crystalline, amorphous & polymorphism. 

  •  Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications.

UNIT -03

  • Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB scale, solubilization, detergency, adsorption at solid interface.

UNIT -04

  • Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants. 

UNIT -05

  • pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.