Free radicals in Diabetes mellitus, Inflammation, Ischemic reperfusion injury, Cancer, Atherosclerosis, Free radicals in brain metabolism and pathology, kidney damage, muscle damage. Free radicals involvement in other disorders. Free- radicals theory of ageing. Antioxidants: Endogenous antioxidants– enzymatic and non-enzymatic antioxidant defence, Superoxide dismutase, catalase, Glutathione peroxidase, Glutathione, Vitamin C, Vitamin E, αLipoic acid, melatonin. Synthetic antioxidants: Butylated hydroxy Toluene, Butylated hydroxy Anisole. Functional foods for chronic disease prevention.