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NOVEL DRUG DELIVERY SYSTEMS (NDDS) BP704T
UNIT -01
- Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations. Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.
UNIT -02
- Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications.
- Mucosal Drug Delivery system: Introduction, Principles of bioadhesion/mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems.
- Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, concept of implants and osmotic pump.
UNIT -03
- Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches.
- Gastro-retentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS– Floating, high density systems, inflatable and gastro-adhesive systems and their applications.
- Naso-pulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers.
UNIT -04
Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications.
UNIT -05
- Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome– Preliminary study, ocular formulations and ocuserts.
- Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications.