PUBLIC HEALTH PHARMACY

MEDICINAL CHEMISTRY – III BP601T

UNIT -01

  •  Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. 
  • β-Lactam antibiotics: Penicillin, Cephalosporin, β-Lactamase inhibitors, Monobactams. 
  • Aminoglycosides: Streptomycin, Neomycin, Kanamycin. 
  • Tetracycline: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline. 

UNIT -02

  • Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. 
  • Macrolide: Erythromycin Clarithromycin, Azithromycin. 
  • Miscellaneous: Chloramphenicol*, Clindamycin. 
  • Prodrugs: Basic concepts and application of prodrugs design. 
  • Antimalarial: Etiology of malaria. 
  • Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. 
  • Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil. 
  • Miscellaneous: Pyrimethamine, Artesunate, Artemether, Atovaquone. 

UNIT -03

  • Anti-tubercular Agents: 
  • Synthetic anti tubercular agents: Isoniazid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.* 
  • Ant-tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine, Streptomycin, Capreomycin sulphate. 
  • Urinary tract anti-infective agents: 
  • Quinolones: SAR of quinolones, Nalidixic Acid, Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin. 
  • Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine. 
  • Antiviral agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Ganciclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirdine, Ribavirin, Saquinavir, Indinavir, Ritonavir.  

UNIT -04

  • Antifungal agents: 

  • Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. 

  • Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconazole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate.* 

  • Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. 

  • Anthelmintic: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantel, Ivermectin. 

  • Sulphonamides and Sulfones: Historical development, chemistry, 

  • classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxazole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. 

  • Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole. Sulfones: Dapsone*.

UNIT -05

  • Introduction to Drug Design 
  • Various approaches used in drug design. 
  • Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammett’s electronic parameter, Taft’s steric parameter and Hansch analysis. 
  • Pharmacophore modeling and docking techniques. 
  • Combinatorial Chemistry: Concept and applications of combinatorial Chemistry: Solid phase and solution phase synthesis.